Journal article
Body size indicators and risk of gallbladder cancer: Pooled analysis of individual-level data from 19 prospective cohort studies
PT Campbell, CC Newton, CM Kitahara, AV Patel, P Hartge, J Koshiol, KA McGlynn, HO Adami, AB De Gonzalez, LEB Freeman, L Bernstein, JE Buring, ND Freedman, YT Gao, GG Giles, MJ Gunter, M Jenab, LM Liao, RL Milne, K Robien Show all
Cancer Epidemiology Biomarkers and Prevention | Published : 2017
Abstract
Background: There are few established risk factors for gallbladder cancer beyond gallstones. Recent studies suggest a higher risk with high body mass index (BMI), an indicator of general heaviness, but evidence from other body size measures is lacking. Methods: Associations of adult BMI, young adult BMI, height, adult weight gain, waist circumference (WC), waist-height ratio (WHtR), hip circumference (HC), and waist-hip ratio (WHR) with gallbladder cancer risk were evaluated. Individual-level data from 1,878,801 participants in 19 prospective cohort studies (14 studies had circumference measures) were harmonized and included in this analysis. Multivariable Cox proportional hazards regression..
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Funding Acknowledgements
The AHS was funded by the Intramural Program of the NIH, National Cancer Institute (Z01 P010119) and the National Institute of Environmental Health Sciences (Z01 ES 049030-11). The BCDDP Follow-up Study has been supported by the Intramural Research Program of the NCI, NIH. The American Cancer Society funds the creation, maintenance, and updating of the CPS-II cohort. The CTS was supported by NCI grants R01 CA 77398 and K05 CA136967 (awarded to L. Bernstein). The coordination of the EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by Danish Cancer Society, Denmark; Ligue Contre le Cancer, France; Institut Gustave Roussy, France; Mutuelle Generale de l'Education Nationale, France; Institut National de la Sante et de la Recherche Medicale, France; Deutsche Krebshilfe, Germany; Deutsches Krebsforschungszentrum and Federal Ministry of Education and Research, Germany; Hellenic Health Foundation, Greece; Italian Association for Research on Cancer; National Research Council, Italy; Dutch Ministry of Public Health, Welfare and Sports, the Netherlands; Netherlands Cancer Registry, the Netherlands; LK Research Funds, the Netherlands; Dutch Prevention Funds, the Netherlands; Dutch ZON (Zorg Onderzoek Nederland), the Netherlands; World Cancer Research Fund, London, UK; Statistics Netherlands, the Netherlands; European Research Council, Norway; Health Research Fund, Regional Governments of Andalucia, Asturias, Basque Country, Murcia (project no. 6236) and Navarra, ISCIII RETIC (RD06/0020/0091), Spain; Swedish Cancer Society, Sweden; Swedish Scientific Council, Sweden; Regional Government of Skane and Vasterbotten, Sweden; Cancer Research United Kingdom; Medical Research Council, United Kingdom; Stroke Association, United Kingdom, British Heart Foundation, United Kingdom; Department of Health, Food Standards Agency, United Kingdom; and Wellcome Trust, United Kingdom. The IWHS is supported by a grant from the NCI (R01 CA39742). The MCCS receives core funding from the Cancer Council Victoria and is additionally supported by grants from the Australian NHMRC (209057, 251533, 396414, and 504715). The NYUWHS is supported by grant R01 CA 098661 and Center grant CA 016087 from the NCI and by Center grant ES 0002. The NIH-AARP Diet and Health Study (NIH-AARP) was supported by the Intramural Research Program of the NCI, NIH. The PHS was supported by grants CA 97193, CA 34944, CA 40360, HL 26490, and HL 34595 from the NIH. The PLCO Cancer Screening Trial is supported by contracts from the NCI. SISTER was supported by the Intramural Research Program of the NIH, National Institute of Environmental Health Sciences (Z01-ES044005). The SMC was supported by the Swedish Research Council, Swedish Council for Working Life and Social Research, and the Swedish Cancer Foundation. The SMHS was supported by grants (R01 CA082729 and UM1 CA173640) from the NIH. The SWHS was supported by grants R37 CA070867 and UM1 CA182910 from the NCI and in part by the NCI intramural program (N02 CP1101066). The VITAL study was supported by the NIH grant K05-CA154337 (National Cancer Institute and Office of Dietary Supplements). The WHS was supported by CA047988, HL043851, HL080467, and HL099355. The WLHS project was supported by the Swedish Research Council (grant number 521-2011-295) and a Distinguished Professor Award at Karolinska Institutet to Hans-Olov Adami, grant number: 2368/10-221.